Home Health 11 Herbs and Supplements to Help Fight Depression

11 Herbs and Supplements to Help Fight Depression


Depression is a mood disorder that affected 27 million people in the United States alone. The actual number thought to be higher.  Many people do not seek treatment for depression for some reason. Below are 5 classifications of depression that share the feeling of being empty, sadness, cognitive changes, and irritable mood.

  • Major Depressive Disorder
  • Persistent depressive disorder
  • Premenstrual dysphoric disorder
  • Disruptive mood dysregulation disorder
  • Depressive disorder due to other medical conditions

Depression is treated with mediation and psychotherapy. Life changes include dietary changes, the addition of exercise, and taking certain supplements. These changes may also help people with depressive disorder. For example, research name some specific herbs and elements that treat depressive disorder symptoms as well as treat people with depression

Here are 11 Supplements for Depressive Disorder Treatments

Omega-3 Fatty Acid

Omega 3 fatty acid is an essential fat, this means, must add them into your diet. Some studies reveal that omega-3 helps to treat depression. A 2020 analysis of randomized control trials including 638 women shows that omega-3 treats depressive disorder in pregnant and postpartum depression. EPA and DHA are two types of omega-3 and both are present in seafood. Another review of 26 studies including 2160 participants found that omega-3 supplements exerted overall positive effects on the treatment of depressive symptoms.

Specifically, researches showed that 60% EPA in a 1 gram of dose or less is most effective. While these findings are promising other studies have mixed results. Omega-3 supplements are a well-tolerated and healthy addition to your diet if it lacks fatty fish. They may also help treat depression in certain populations.

NAC (N-acetylcysteine)

NAC is a precursor to the amino acids, L-cysteine and glutathione. Glutathione is considered one of the most important anti-oxidant in your body. It is critical for regulating inflammation and protecting cells against oxidative damage.

NAC offered several benefits including boosting your body’s glutathione level. Research shows that people with depression are more likely to have higher levels of inflammatory cytokines, interleukins and tumor necrosis factor-alpha.

Taking NAC reduces inflammation and eases depressive symptoms.

NAC also improves neurotransmitter dysregulation. This dysregulation like dopamine and glutamate may be associated with mood disorder schizophrenia among other conditions.

Doses of 2-2.4 grams per day are thought to help to treat psychiatric disorders like depression.


Saffron is bright colored species packed with antioxidant properties. These include carotenoids crocin and crocetin. It showed promising natural treatment for depression. Studies showed that it increases the level of serotonin (mood-boosting neurotransmitter) in the body.

Well, it is unknown how exactly it works. However, one study suggests that saffron inhibits the reuptake of serotonin and makes it stay longer in the brain. A study of five participants showed that supplementing with saffron treats MDD rather than with placebo treatment.

The review found that saffron supplements were similarly effective at reducing depressive symptoms as antidepressant medication.

Vitamin D

Vitamin D is an essential element for the body. Unfortunately, people do not have essential vitamin D levels, including people with depression. Researches show that people with vitamin D have a low or deficient level of vitamin D.

Those with conditions have a lower level of vitamin D than the general public. And people with the lowest level tend to have the most significant depressive symptoms.

Vitamin D may fight depression through several mechanisms including reducing inflammation and protecting against neurocognitive dysfunction. It also regulates the mood.


Rhodiola is an herbal linked with health benefits. It makes the body adapt to stressful situations. It improves stress mechanism. Herb may show antidepressant effects and the ability to enhance nerve cell communication. Some studies show that supplementing with Rhodiola may benefit those with depression.

 Rhodiola treatment shows fewer side effects than actual antidepressant medication. Supplements composed of Rhodiola and saffron reduce depression and anxiety symptoms in adults with mild to moderate depression after 6 weeks.

B Vitamins

B vitamins play a vital role in mood regulations and neurological function. However, B vitamins include folate B12 and B6. They needed for the production and regulation of dopamine, serotonin, and gamma-aminobutyric acid (GABA).

Deficiencies in Vitamin B12 and folate may increase the risk of depression and supplement with these nutrients may lower the symptoms of depression in certain populations.


Zinc is a mineral critical for brain health and neurotransmitter pathways. It also boosts antioxidant and anti-inflammatory properties. Zinc deficiency strongly linked to increased risk of depression and participants when took zinc supplements alongside the antidepressant medication experienced significantly lowered depressive symptoms.


Magnesium is a mineral that benefits those with psychological conditions. The magnesium deficiency is common among people with depressive states. Supplementing with magnesium reduces symptoms of depression as well as treated MDD.

A randomized study of 126 people with mild to moderate depression found that taking 248mg of magnesium per day significantly improves depressive symptoms compared with placebo.


Creatine is an organic acid that plays an important part in maintaining brain energy. Brain levels are involve in the development of depression. Some studies suggest supplementing with 2-10 grams of creatine per day may reduce symptoms of people with MDD.


Depression is a mental disorder that affects millions of people worldwide. Depression can typically treat with therapy and medication. Some people may want to try other safe methods like dietary modifications and supplements to reduce their symptoms. However, before supplement intake, it is important to discuss any supplement with your healthcare professional.



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